Does Progesterone Delay Period After IUI?

After your intrauterine insemination (IUI) procedure, it's understandable if you count down the days until your next period or, hopefully, a positive pregnancy test. However, if your period is late, you might start to wonder what could be the reason. Is it a sign of early pregnancy, or could it be because of the progesterone supplements you are taking?

Does progesterone delay periods after IUI treatment?

Yes, progesterone supplementation can delay the onset of your period after IUI. It's often given after IUI to support the lining of your uterus and the early stages of pregnancy.

These supplements contain the same properties as the natural progesterone your body produces after ovulation, helping to keep the endometrial lining intact and possibly extending the luteal phase.

Even if you don’t get pregnant, progesterone supplements can delay your period by preventing the uterine lining from shedding and beginning your monthly menstruation. 

Why are progesterone supplements taken during IUI?

Progesterone is a vital hormone for preparing and maintaining the uterine lining to support a fertilised egg. After ovulation and IUI, progesterone supplements, such as vaginal suppositories, oral capsules, or injections, are often prescribed during the luteal phase for several reasons:

• To improve the thickness and quality of the endometrial lining, which facilitates implantation.

• To support a developing embryo until the placenta can produce enough hormones on its own, usually around 8-10 weeks of pregnancy.

• To help reduce the risk of luteal phase defect, a condition where the body does not produce enough natural progesterone to sustain a potential pregnancy.

• To increase the chance of implantation and decrease the risk of early miscarriage in cases of successful fertilisation. 

Why haven’t I got my period after taking progesterone?

There could be several reasons why your period doesn't start on schedule when using progesterone, or even a few days after you stop taking it:

• You might be pregnant. The most common reason for a missed period after IUI and progesterone support is early pregnancy. In this case, a pregnancy test is recommended, typically 14 days after IUI.

• Progesterone is causing your period to be late. This supplement stops the normal hormone drop that starts your period. Your period may start several days after you stop the medicine.

• Your cycle may be naturally delayed. Every woman’s cycle can vary slightly from month to month, especially when hormonal medications are involved. 

For more information on how progesterone may affect your period and what to expect after IUI, and to receive advice tailored to your unique situation, consider speaking with a fertility specialist. You may contact Thomson Medical to arrange a consultation for personalised guidance on hormone management and early pregnancy care.

What are some other reasons for delays in periods after IUI?

Ovulation induction medication

Medications such as Clomiphene Citrate (Clomid), Letrozole, or injectable gonadotropins are used to stimulate follicle development and ovulation. These medications can sometimes disrupt the natural rhythm of your menstrual cycle, leading to variations in cycle length or delayed periods.

Pregnancy

A successful IUI can result in pregnancy, which naturally halts the menstrual cycle. A missed period is often one of the first signs of pregnancy. A positive pregnancy test will confirm this. 

Cycle variability

Even with ovulation induction and careful monitoring, the body may not always respond the same way each cycle. Follicle growth and hormone levels can vary from person to person, which might cause small shifts in your cycle length and the timing of your periods. 

Stress and other emotional factors

Going through fertility treatments can be emotionally draining, and stress can disrupt the hormonal balance that regulates your cycle and hormone production. Sometimes, emotional or physical stress may delay your ovulation or a missed period.

Underlying health conditions

Conditions such as thyroid disorders, polycystic ovary syndrome (PCOS), and elevated prolactin levels (hyperprolactinemia) can interfere with regular ovulation and menstruation. If your cycles are often irregular, your doctor may look into these possible causes.

Miscarriage

In some cases, a fertilised egg implants, but it doesn't develop properly. This can lead to an early miscarriage. These conditions can make your period come later and may be accompanied by heavier or more painful bleeding once your period starts. Some women don't even realise they were briefly pregnant.

Timing and procedure factors

Sometimes, ovulation or insemination timing can differ, even with ultrasound and hormone tracking. This can cause slight inaccuracies in cycle day predictions. Your period might feel late, even if it’s on time for your body. 

When should I contact my fertility specialist?

It’s important to reach out to your doctor or fertility clinic if:

• Your pregnancy test is negative, and you haven't had your period 14 to 16 days after IUI.

• You’re experiencing unusual symptoms, such as persistent spots, severe cramps, or heavy bleeding.

• You are unsure when or whether to stop taking progesterone supplements.

• You need clarification on when to take a pregnancy test or how to proceed with your treatment cycle.

• You have missed your period and have a history of irregular cycles, PCOS, or thyroid problems. 

FAQ

Does IUI cause a delayed period?

Will taking progesterone make my period late?

Yes, progesterone supplementation can make your period to be late. This is a common and expected side effect. As long as you are on progesterone, your body may not initiate menstruation. If you're not pregnant, your period will usually start a few days after stopping the medication. 

What are the side effects of progesterone after IUI?

When to stop progesterone after IUI? 

What are the signs of low progesterone?

Is it better to have high or low progesterone?

For conception and early pregnancy, it’s better to have adequately high progesterone. High progesterone keeps the uterine lining healthy and helps the embryo implant. However, excessively high levels from supplementation can cause side effects. Balance is key; progesterone levels should be high enough to support pregnancy but not so high that they cause intolerable side effects. 

Does progesterone drop after implantation?

The information provided is intended for general guidance only and should not be considered medical advice. For personalised recommendations based on your medical conditions, request an appointment with Thomson Medical.