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Is IUI Painful? What to Expect

IUI is usually not painful, but some people may feel mild cramping or discomfort during the procedure. Learn what to expect and tips for easing anxiety

Getting Pregnant

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Published on 12 Aug 2025

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By Thomson Team

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It’s completely normal to feel a bit nervous before your first intrauterine insemination (IUI), especially when you’re not sure what it’ll feel like. Many people wonder, “Will it be painful?” Most describe IUI as a quick, minimally invasive procedure with only mild cramping or slight pressure when the catheter is inserted. Understanding what to expect and knowing any discomfort is brief can ease your worries and help you feel more confident throughout your IUI journey.

What should I expect during the IUI procedure?

ovulation timing

IUI is quite a straightforward fertility treatment that involves careful preparation in determining the ovulation time, preparing the sperm sample, and the insemination itself.

Ovulation

Your healthcare provider will determine when you're ovulating either by blood tests or transvaginal ultrasounds. Ovulation usually occurs around 10 to 16 days after the first day of your menstrual cycle.

The timing of ovulation is critical to ensuring sperm is injected at the right time.

To support ovulation induction and ensure egg retrieval, your doctor may give you human chorionic gonadotropin (hCG) injections or other fertility medications, such as Clomiphene Citrate (Clomid).

The insemination procedure usually occurs within 24 to 36 hours after the luteinising hormone (LH) is detected (either in your blood or urine) or after the hCG injection.

Semen sample preparation

Your partner will need to provide a fresh sperm sample on the day of the IUI procedure. However, in certain situations, your partner may be able to provide the sample in advance, which your doctor will preserve in a frozen state until it is needed.

Once the sperm sample has been collected, it is prepared for insemination by a process called "sperm washing," which extracts a concentrated amount of healthy sperm.

Insemination

On the day of your procedure, your fertility specialist will ask you to lie down on an exam table much like during a routine pelvic exam. Then they'll insert a speculum into your vagina, similar to what happens during a Pap smear test.

Next, a catheter is inserted through your cervix into your uterus. Finally, your healthcare provider injects the washed sperm sample into your uterus.

Once the sperm has been injected, you will be asked to lie down for 10–30 minutes. Your doctor may also prescribe progesterone after the procedure to help maintain the lining of your uterus, which can improve the chances of implantation. The entire procedure typically does not need anaesthesia.

To find out if the IUI procedure has been successful, you can take a pregnancy test approximately two weeks later.

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Is the IUI procedure painful?

The IUI procedure shouldn't be painful. However, you may experience some cramping or a pinching sensation when the catheter is inserted or have mild cramping and discomfort during and right after insemination.

You may feel some anxiety over the procedure, and it can sometimes heighten your sensitivity to pain, but most describe IUI as uncomfortable rather than painful.

Experiencing severe pain during the IUI process is uncommon.

Will I feel pain after the IUI procedure?

While IUI is typically quick and not very painful, you may feel some discomfort after the procedure. One common post-IUI symptom is abdominal cramping, similar to menstrual cramps. This cramping is generally minor and can be managed with rest and medication.

Various factors can lead to these cramps after IUI:

  • Catheter insertion: The process involves inserting a catheter through the cervix to place sperm into the uterus. This can mildly irritate the area, leading to some discomfort afterwards.

  • Ovulation: Cramps may also occur due to ovulation, a normal bodily function. If fertility medications are used to induce ovulation, the likelihood of experiencing cramps increases.

If you experience heavy bleeding, fever, or severe pain, contact your fertility clinic immediately. Request an appointment with Thomson Medical today.

What are some factors that may affect discomfort during IUI?

Discomfort during IUI can vary depending on several factors, including:

  • Cervical sensitivity:

    • Some women may have more sensitive cervixes, which can lead to increased discomfort during catheter insertion.

  • Anxiety and stress:

    • Anxiety and stress can heighten your perception of pain. Engaging in deep breathing exercises and relaxation techniques can help mitigate this effect.

  • Previous experiences:

    • If you have had previous painful gynaecological experiences, you may expect more pain, potentially increasing your sensitivity.

  • Doctor's technique:

    • The degree of pain may vary depending on the skill and method used by the medical professional doing the IUI.

  • Presence of pre-existing gynaecological conditions:

    • Conditions such as endometriosis, fibroids, chronic pelvic inflammatory disease, or previous cervical procedures can make the cervix or uterus more sensitive.

    • Scar tissue or inflammation can also narrow or distort the cervical canal, making the insertion of the IUI catheter more challenging and potentially more uncomfortable.

  • Cervical or uterine anatomy, such as a tilted uterus:

    • Anatomical variations like a retroverted (tilted backwards) or anteverted (tilted forwards) uterus can alter the alignment between the cervix and uterus.

    • This misalignment may make it more difficult for the clinician to gently and smoothly guide the catheter through the cervix into the uterus.

How can I manage discomfort during IUI?

how to manage discomfort after iui

Any discomfort after IUI is usually mild and fades quickly. However, there are simple ways to ease any lingering cramping or soreness.

Some pain relief options include:

  • Over-the-counter pain relief medications:

    • If you’re feeling a bit sore and need relief, you might consider taking paracetamol or ibuprofen. Just check with your fertility specialist first to be sure it’s safe for you.

  • Gentle heat:

    • Applying a warm water bottle to your abdomen can relax muscles and relieve cramps.

  • Rest:

    • Give your body the time it needs to recuperate. Avoid strenuous activities or heavy lifting for at least 24 hours after the procedure.

  • Hydration:

    • Drink plenty of water to keep yourself well-hydrated. Staying hydrated can help you feel better and support your body’s healing.

If you are unsure how to mitigate the discomfort after IUI, you can consult your fertility specialist directly. It's crucial to follow any specific aftercare instructions provided by your doctor to ensure optimal recovery and increase the chances of success.

Is there any way I can relax before IUI?

Relaxing before your IUI procedure can make the experience much more comfortable, both physically and emotionally. Here are several things you can do to relax before your IUI procedure:

  • Deep breathing:

    • Practise slow, deep breathing exercises, such as inhaling for four counts, holding for four counts, and exhaling for four counts.

  • Arrive early for your appointment:

    • Give yourself plenty of time to check in and settle before your appointment so you’re not rushed or flustered.

  • Wearing comfortable items:

    • Wear loose, comfortable clothing to help you feel at ease.

  • Ask questions:

    • Consult with your fertility specialists in advance if you have any concerns about the procedure.

    • Ask your fertility doctor about strategies to minimise discomfort, such as pain relief options or positioning adjustments during the procedure.

When should I inform my doctor about the discomfort?

when to inform doctor about discomfort after iui

If you're taking fertility medications for IUI, you should contact your fertility specialist if any of the following happens:

  • Severe or persistent pelvic or abdominal pain

  • Heavy vaginal bleeding

  • Fever or signs of infection

  • Nausea and vomiting

  • Shortness of breath

  • Sudden weight gain

  • Dizziness or lightheadedness

FAQ

How painful is the IUI procedure?

For most, IUI is not painful; it’s often described as mildly uncomfortable, like a Pap smear or routine gynaecological exam.

Can you get pregnant naturally after IUI?

Yes, you can still get pregnant naturally in subsequent cycles, as IUI does not affect your natural fertility long-term.

How long does pain last after IUI?

Mild cramping or discomfort, if any, typically resolves within a few hours to a day after the procedure.

Which is more painful, IUI or HSG?

Generally, an HSG (hysterosalpingogram) is reported to be a bit more uncomfortable or painful than IUI, as it involves injecting dye into the uterus and fallopian tubes.

Is IUI successful on the first try?

IUI can be successful on the first try, but pregnancy rates per cycle vary depending on age, diagnosis, and other factors. Multiple cycles are sometimes needed.

Does IUI feel like a Pap smear?

Yes, many people find IUI feels similar to a Pap smear; there may be pressure and brief discomfort, but it is usually not painful.

What is the disadvantage of IUI?

Disadvantages include the need for multiple appointments, the possibility of multiple attempts, lower success rates compared to IVF, and the potential for mild discomfort.

Are periods more painful after IUI?

Most people do not experience more painful periods after IUI. If you notice significant changes, let your clinic know. If you have concerns or wish to discuss ways to make your IUI experience more comfortable, do not hesitate to reach out to your fertility care team.

The information provided is intended for general guidance only and should not be considered medical advice. For personalised recommendations and tailored advice based on your unique situations, please consult a specialist at Thomson Medical. Request an appointment with Thomson Medical today.

For more information, contact us:

Thomson Fertility Centre

Thomson Specialists (Women's Health)

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